Genetic basis of natural antibody titers of young healthy pigs
The genetic foundation of pure antibody titers of younger wholesome pigs and relationships with illness resilience
Background: Sickness resilience is the pliability to maintain up effectivity beneath pathogen publicity nonetheless is troublesome to select for on account of breeding populations are raised beneath extreme properly being. Alternative for resilience requires a trait that is heritable, simple to measure on healthful animals, and genetically correlated with resilience. Pure antibodies (NAb) are important parts of the innate immune system and are found to be heritable and associated to sickness susceptibility in dairy cattle and poultry. Our aim was to research NAb and entire IgG in blood of healthful, youthful pigs as potential indicator traits for sickness resilience.
Outcomes: Data have been from Yorkshire x Landrace pigs, with IgG and IgM NAb (Four antigens) and entire IgG measured by ELISA in blood plasma collected ~ 1 week after weaning, earlier to their publicity to a pure polymicrobial drawback. Heritability estimates have been lower for IgG NAb (0.12 to 0.24, + 0.05) and for entire IgG (0.19 + 0.05) than for IgM NAb (0.33 to 0.53, + 0.07) nonetheless maternal outcomes have been greater for IgG NAb (0.41 to 0.52, + 0.03) and for entire IgG (0.19 + 0.05) than for IgM NAb (0.00 to 0.10, + 0.04).
Phenotypically, IgM NAb titers have been moderately correlated with each other (frequent 0.60), as have been IgG NAb titers (frequent 0.42), nonetheless correlations between IgM and IgG NAb titers have been weak (frequent 0.09). Phenotypic correlations of entire IgG have been cheap with NAb IgG (frequent 0.46) nonetheless weak with NAb IgM (frequent 0.01).
Estimates of genetic correlations amongst NAb confirmed associated patterns nonetheless with small SE, with estimates averaging 0.76 amongst IgG NAb, 0.63 amongst IgM NAb, 0.17 between IgG and IgM NAb, 0.64 between entire IgG and IgG NAb, and 0.13 between entire IgG and IgM NAb. Phenotypically, pigs that survived had barely elevated ranges of NAb and entire IgG than pigs that died. Genetically, elevated ranges of NAb tended to be associated to raised sickness resilience based totally on lower mortality and fewer parenteral antibiotic therapies. Genome-wide affiliation analyses for NAb titers acknowledged plenty of genomic areas, with plenty of candidate genes for immune response.
Conclusions: Ranges of NAb in blood of healthful youthful piglets are heritable and potential genetic indicators of resilience to polymicrobial sickness.
Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Monoclonal Antibody (Human), APC-Cy7 |
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| 4-CAC060Hu22-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with APC-Cy7. |
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Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Monoclonal Antibody (Human), Biotinylated |
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| 4-CAC060Hu22-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with Biotin. |
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Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Monoclonal Antibody (Human), Cy3 |
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| 4-CAC060Hu22-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with Cy3. |
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Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Monoclonal Antibody (Human), FITC |
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| 4-CAC060Hu22-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with FITC. |
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Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Monoclonal Antibody (Human), HRP |
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| 4-CAC060Hu22-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with HRP. |
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Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Monoclonal Antibody (Human), PE |
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| 4-CAC060Hu22-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with PE. |
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Lamin B1 (LMNB1) Polyclonal Antibody (Human, Pig) |
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| 4-CAF548Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Lamin B1 (LMNB1) |
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Lamin B1 (LMNB1) Polyclonal Antibody (Human, Pig), APC |
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| 4-CAF548Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Lamin B1 (LMNB1). This antibody is labeled with APC. |
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Lamin B1 (LMNB1) Polyclonal Antibody (Human, Pig), APC-Cy7 |
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| 4-CAF548Hu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Lamin B1 (LMNB1). This antibody is labeled with APC-Cy7. |
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Lamin B1 (LMNB1) Polyclonal Antibody (Human, Pig), Biotinylated |
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| 4-CAF548Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Lamin B1 (LMNB1). This antibody is labeled with Biotin. |
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Lamin B1 (LMNB1) Polyclonal Antibody (Human, Pig), Cy3 |
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| 4-CAF548Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Lamin B1 (LMNB1). This antibody is labeled with Cy3. |
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Lamin B1 (LMNB1) Polyclonal Antibody (Human, Pig), FITC |
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| 4-CAF548Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Lamin B1 (LMNB1). This antibody is labeled with FITC. |
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Lamin B1 (LMNB1) Polyclonal Antibody (Human, Pig), HRP |
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| 4-CAF548Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Lamin B1 (LMNB1). This antibody is labeled with HRP. |
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Lamin B1 (LMNB1) Polyclonal Antibody (Human, Pig), PE |
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| 4-CAF548Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Lamin B1 (LMNB1). This antibody is labeled with PE. |
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Lamin B1 (LMNB1) Monoclonal Antibody (Human) |
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| 4-CAF548Hu22 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin B1 (LMNB1) |
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Lamin B1 (LMNB1) Monoclonal Antibody (Human), APC |
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| 4-CAF548Hu22-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin B1 (LMNB1). This antibody is labeled with APC. |
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Lamin B1 (LMNB1) Monoclonal Antibody (Human), APC-Cy7 |
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| 4-CAF548Hu22-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin B1 (LMNB1). This antibody is labeled with APC-Cy7. |
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Lamin B1 (LMNB1) Monoclonal Antibody (Human), Biotinylated |
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| 4-CAF548Hu22-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin B1 (LMNB1). This antibody is labeled with Biotin. |
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Lamin B1 (LMNB1) Monoclonal Antibody (Human), Cy3 |
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| 4-CAF548Hu22-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin B1 (LMNB1). This antibody is labeled with Cy3. |
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Lamin B1 (LMNB1) Monoclonal Antibody (Human), FITC |
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| 4-CAF548Hu22-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin B1 (LMNB1). This antibody is labeled with FITC. |
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Lamin B1 (LMNB1) Monoclonal Antibody (Human), HRP |
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| 4-CAF548Hu22-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin B1 (LMNB1). This antibody is labeled with HRP. |
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Lamin B1 (LMNB1) Monoclonal Antibody (Human), PE |
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| 4-CAF548Hu22-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin B1 (LMNB1). This antibody is labeled with PE. |
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Lamin A/C (LMNA) Polyclonal Antibody (Human) |
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| 4-CAF550Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Lamin A/C (LMNA) |
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Lamin A/C (LMNA) Polyclonal Antibody (Human), APC |
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| 4-CAF550Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with APC. |
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Lamin A/C (LMNA) Polyclonal Antibody (Human), APC-Cy7 |
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| 4-CAF550Hu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with APC-Cy7. |
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Lamin A/C (LMNA) Polyclonal Antibody (Human), Biotinylated |
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| 4-CAF550Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with Biotin. |
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Lamin A/C (LMNA) Polyclonal Antibody (Human), Cy3 |
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| 4-CAF550Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with Cy3. |
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Lamin A/C (LMNA) Polyclonal Antibody (Human), FITC |
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| 4-CAF550Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with FITC. |
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Lamin A/C (LMNA) Polyclonal Antibody (Human), HRP |
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| 4-CAF550Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with HRP. |
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Lamin A/C (LMNA) Polyclonal Antibody (Human), PE |
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| 4-CAF550Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with PE. |
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Lamin A/C (LMNA) Monoclonal Antibody (Human) |
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| 4-CAF550Hu22 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin A/C (LMNA) |
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Lamin A/C (LMNA) Monoclonal Antibody (Human), APC |
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| 4-CAF550Hu22-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with APC. |
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Lamin A/C (LMNA) Monoclonal Antibody (Human), APC-Cy7 |
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| 4-CAF550Hu22-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with APC-Cy7. |
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Lamin A/C (LMNA) Monoclonal Antibody (Human), Biotinylated |
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| 4-CAF550Hu22-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with Biotin. |
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Lamin A/C (LMNA) Monoclonal Antibody (Human), Cy3 |
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| 4-CAF550Hu22-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with Cy3. |
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Lamin A/C (LMNA) Monoclonal Antibody (Human), FITC |
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| 4-CAF550Hu22-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with FITC. |
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Lamin A/C (LMNA) Monoclonal Antibody (Human), HRP |
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| 4-CAF550Hu22-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with HRP. |
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Lamin A/C (LMNA) Monoclonal Antibody (Human), PE |
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| 4-CAF550Hu22-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with PE. |
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Polyclonal Antibody (Human) |
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| 4-CAG369Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) |
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Polyclonal Antibody (Human), APC |
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| 4-CAG369Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with APC. |
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Polyclonal Antibody (Human), APC-Cy7 |
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| 4-CAG369Hu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with APC-Cy7. |
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Polyclonal Antibody (Human), Biotinylated |
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| 4-CAG369Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with Biotin. |
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Polyclonal Antibody (Human), Cy3 |
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| 4-CAG369Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with Cy3. |
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Polyclonal Antibody (Human), FITC |
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| 4-CAG369Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with FITC. |
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Polyclonal Antibody (Human), HRP |
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| 4-CAG369Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with HRP. |
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Polyclonal Antibody (Human), PE |
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| 4-CAG369Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with PE. |
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Monoclonal Antibody (Human) |
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| 4-CAG369Hu22 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) |
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Monoclonal Antibody (Human), APC |
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| 4-CAG369Hu22-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with APC. |
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Monoclonal Antibody (Human), APC-Cy7 |
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| 4-CAG369Hu22-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with APC-Cy7. |
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Monoclonal Antibody (Human), Biotinylated |
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| 4-CAG369Hu22-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with Biotin. |
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Monoclonal Antibody (Human), Cy3 |
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| 4-CAG369Hu22-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with Cy3. |
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Monoclonal Antibody (Human), FITC |
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| 4-CAG369Hu22-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with FITC. |
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Monoclonal Antibody (Human), HRP |
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| 4-CAG369Hu22-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with HRP. |
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Monoclonal Antibody (Human), PE |
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| 4-CAG369Hu22-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with PE. |
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Voltage Dependent Anion Channel Protein 1 (VDAC1) Polyclonal Antibody (Human) |
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| 4-CAG901Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1) |
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Voltage Dependent Anion Channel Protein 1 (VDAC1) Polyclonal Antibody (Human), APC |
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| 4-CAG901Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with APC. |
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Voltage Dependent Anion Channel Protein 1 (VDAC1) Polyclonal Antibody (Human), APC-Cy7 |
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| 4-CAG901Hu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with APC-Cy7. |
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Voltage Dependent Anion Channel Protein 1 (VDAC1) Polyclonal Antibody (Human), Biotinylated |
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| 4-CAG901Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with Biotin. |
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Voltage Dependent Anion Channel Protein 1 (VDAC1) Polyclonal Antibody (Human), Cy3 |
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| 4-CAG901Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with Cy3. |
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Voltage Dependent Anion Channel Protein 1 (VDAC1) Polyclonal Antibody (Human), FITC |
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| 4-CAG901Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with FITC. |
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Voltage Dependent Anion Channel Protein 1 (VDAC1) Polyclonal Antibody (Human), HRP |
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| 4-CAG901Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with HRP. |
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Voltage Dependent Anion Channel Protein 1 (VDAC1) Polyclonal Antibody (Human), PE |
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| 4-CAG901Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with PE. |
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Voltage Dependent Anion Channel Protein 1 (VDAC1) Monoclonal Antibody (Human) |
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| 4-CAG901Hu22 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1) |
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Voltage Dependent Anion Channel Protein 1 (VDAC1) Monoclonal Antibody (Human), APC |
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| 4-CAG901Hu22-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with APC. |
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Voltage Dependent Anion Channel Protein 1 (VDAC1) Monoclonal Antibody (Human), APC-Cy7 |
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| 4-CAG901Hu22-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with APC-Cy7. |
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Voltage Dependent Anion Channel Protein 1 (VDAC1) Monoclonal Antibody (Human), Biotinylated |
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| 4-CAG901Hu22-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with Biotin. |
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Voltage Dependent Anion Channel Protein 1 (VDAC1) Monoclonal Antibody (Human), Cy3 |
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| 4-CAG901Hu22-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with Cy3. |
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Voltage Dependent Anion Channel Protein 1 (VDAC1) Monoclonal Antibody (Human), FITC |
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| 4-CAG901Hu22-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with FITC. |
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Voltage Dependent Anion Channel Protein 1 (VDAC1) Monoclonal Antibody (Human), HRP |
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| 4-CAG901Hu22-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with HRP. |
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Voltage Dependent Anion Channel Protein 1 (VDAC1) Monoclonal Antibody (Human), PE |
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| 4-CAG901Hu22-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with PE. |
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Human Angiotensin II (AngII) CLIA Kit |
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| 4-CCA005Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Angiotensin II (AngII)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
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Human Glycated Hemoglobin A1c (HbA1c) CLIA Kit |
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| 4-CCA190Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Glycated Hemoglobin A1c (HbA1c)serum, plasma and erythrocyte lysates |
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Human Anti-Mullerian Hormone (AMH) CLIA Kit |
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| 4-CCA228Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Anti-Mullerian Hormone (AMH)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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General Bovine Serum Albumin (BSA) CLIA Kit |
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| 4-CCA248Ge | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Bovine Serum Albumin (BSA)Serum, plasma and other biological fluids |
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Cattle Substance P (SP) CLIA Kit |
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| 4-CCA393Bo | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Cattle Substance P (SP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
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Dog Substance P (SP) CLIA Kit |
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| 4-CCA393Ca | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Dog Substance P (SP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
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Guinea pig Substance P (SP) CLIA Kit |
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| 4-CCA393Gu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Guinea pig Substance P (SP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
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Human Substance P (SP) CLIA Kit |
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| 4-CCA393Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Substance P (SP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Mouse Substance P (SP) CLIA Kit |
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| 4-CCA393Mu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Mouse Substance P (SP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
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Rat Substance P (SP) CLIA Kit |
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| 4-CCA393Ra | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat Substance P (SP)serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
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General Dehydroepiandrosterone (DHEA) CLIA Kit |
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| 4-CCA398Ge | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Dehydroepiandrosterone (DHEA)serum, plasma and other biological fluids |
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ELISA Kit for Luteinizing Hormone (LH) |
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| 4-CCA441Mu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Luteinizing Hormone (LH) in samples from Serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. |
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Rat Luteinizing Hormone (LH) CLIA Kit |
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| 4-CCA441Ra | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat Luteinizing Hormone (LH)serum, plasma and other biological fluids |
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Human C-Peptide (CP) CLIA Kit |
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| 4-CCA447Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human C-Peptide (CP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
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Rat C-Peptide (CP) CLIA Kit |
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| 4-CCA447Ra | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat C-Peptide (CP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
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Human Insulin (INS) CLIA Kit |
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| 4-CCA448Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Insulin (INS)Serum, plasma, cell culture supernates and other biological fluids |
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Rat Insulin (INS) CLIA Kit |
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| 4-CCA448Ra | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat Insulin (INS)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
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General Thyroxine (T4) CLIA Kit |
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| 4-CCA452Ge | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Thyroxine (T4)Serum, plasma and other biological fluids |
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General Triiodothyronine (T3) CLIA Kit |
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| 4-CCA453Ge | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Triiodothyronine (T3)Serum, plasma and other biological fluids |
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General Estriol (E3) CLIA Kit |
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| 4-CCA455Ge | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Estriol (E3)Serum, plasma and other biological fluids |
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Affiliation analysis of the surfactant protein-C gene to childhood bronchial bronchial asthma
Objectives: This analysis objectives to clarify the molecular variability inside the SFTPC gene in a childhood persistent respiratory sickness, bronchial bronchial asthma, inside the Tunisian inhabitants and to ascertain the implications based totally on a case-control analysis of p.Thr138Asn (T138N) and p.Ser186Asn (S186N) variants.
Methods: We used direct sequencing for the genotyping of the SFTPC gene inside 101 asthmatic children. The analysis of T138N and S186N variants in 110 controls is carried out by the PCR-RFLP methodology. Outcomes: The molecular analysis revealed 26 variants along with 24 intronic variations and a pair of exonic variations (T138N and S186N) with respective frequencies of 16.8% and 18.3%. We carried out a case-control analysis of the two acknowledged exonic
variations. A particular genotypic and allelic distribution between the two groups was well-known. Solely the T138N polymorphism confirmed a significant affiliation with bronchial bronchial asthma sickness (p < 10-3).
Statistical analysis elaborated Four haplotypes with the following frequencies in victims vs controls: 138Thr-186Ser (79.5% vs 57.6%), 138Thr-186Asn (3.7% vs 7.8%), 138Asn-186Thr (2.2% vs 20.2%) and 138Asn-186Asn (14.6% vs 14.4%). A serious distinction (p < 10-3) was highlighted in haplotype distribution. The 138Asn-186Ser (OR [95%CI] = 0.14[0.04-0.54], p = 0.004, R2=0.93) and 138Thr-186Asn (OR [95%CI] = 0.35[0.12-0.54], p = 0.047, R2=0.88) haplotypes confirmed a dangerous affiliation with bronchial bronchial asthma which might characterize a defending situation in opposition to the sickness.
Conclusion: In Tunisia, this work constitutes the first report inside the SFTPC gene and highlights the genetic variability of the SFTPC gene in bronchial bronchial asthma. As a consequence of this truth, the case-controls analysis may be useful inside the analysis of surfactant proteins dysfunction in persistent respiratory sickness at an early age.
SUMO4 small interfering RNA attenuates invasion and migration by the JAK2/STAT3 pathway in non-small cell lung most cancers cells
- Small ubiquitin-like modifier 4 (SUMO4) is the latest member of the sumoylation family, which boosts the stableness of protein, regulates the distribution and localization of the protein, and impacts the transcription train of the protein. However, the perform of SUMO4 in non-small cell lung most cancers (NSCLC) has not however been reported.
- The present analysis first demonstrated that SUMO4 was upregulated in various tissues from victims with NSCLC. Immunohistochemistry was carried out to show the expression diploma of SUMO4 in lung most cancers tumor tissues. Following the transfection, The EMT standing and signaling pathway activation regulated by SUMO4-siRNA was assessed by western blotting.
- The Transwell and wound therapeutic assays had been carried out to analysis the regulatory impression of SUMO4-siRNA on cell migration and invasion. Cell Counting Gear-Eight assay was carried out to analysis whether or not or not SUMO4-siRNA affected the chemosensitivity of the NSCLC cells to cisplatin. Statistical analysis of immunohistochemical outcomes from the tissues confirmed that the overexpression of SUMO4 was significantly associated to intercourse, tumor sort, historic previous of smoking, T stage and poor prognosis.
- It was moreover acknowledged that SUMO4 small interfering RNA attenuated invasion and migration in NSCLC cell traces, as successfully chemosensitivity to cisplatin by the inhibition of the JAK2/STAT3 pathway. In conclusion, SUMO4 would possibly play a vital perform inside the poor prognosis of victims with NSCLC. The present analysis signifies that SUMO4 may be a potential therapeutic aim for NSCLC.
English