Familial dilated cardiomyopathy brought on by a novel variant

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Subsequent era sequencing reveals a novel pathogenic variant within the ATMgene

Introduction: Ataxia telangiectasia (A-T) is a unusual autosomal recessive multisystemic sickness. Victims with the A-T syndrome present a broad spectrum of sickness phenotypes. The ATM (ataxia telangiectasia mutated) gene, the one causative gene for A-T.

Methodology: A affected particular person of Persian origin presenting with typical A-T was referred to our genetics center for specialised genetic counseling and testing. Centered next-generation sequencing (NGS) was utilized. Sanger sequencing was used to substantiate the candidate variant. Modeling was carried out using the SWISS-MODEL server.Outcomes: A homozygous stop-gain variant c.829G > T (p.E277*) was found inside the ATM gene. This variant was confirmed by Sanger sequencing and modeling of native building and truncated building was carried out.

Conclusion: Up to now, just a few pathogenic variants of the ATM gene have been reported from the Iranian inhabitants. The discovering has implications in molecular diagnostic for A-T in Iran.

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Polyclonal EGF Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human EGF . This antibody is tested and proven to work in the following applications:

Polyclonal Eotaxin/CCL11 Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Eotaxin/CCL11 . This antibody is tested and proven to work in the following applications:

Polyclonal FGF-1 Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF-1 . This antibody is tested and proven to work in the following applications:

Polyclonal FGF-2 Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF-2 . This antibody is tested and proven to work in the following applications:

Polyclonal FGF-2 Antibody

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Polyclonal KGF/FGF-7 Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human KGF/FGF-7 . This antibody is tested and proven to work in the following applications:

Polyclonal FGF-8 Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF-8 . This antibody is tested and proven to work in the following applications:

Polyclonal FGF-10 Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF-10 . This antibody is tested and proven to work in the following applications:

Polyclonal FGF-10 Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF-10 . This antibody is tested and proven to work in the following applications:

Polyclonal Flt3 Ligand Antibody

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Polyclonal Fractalkine Antibody

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Polyclonal G-CSF Antibody

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Polyclonal IL-7 Antibody

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Polyclonal IL-9 Antibody

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Polyclonal IL-17A Antibody

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Polyclonal IL-17F Antibody

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Polyclonal IL-33 Antibody

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Polyclonal sRANK Ligand Antibody

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Polyclonal IFN gamma Antibody

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Polyclonal IFN gamma Antibody

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Polyclonal IGF-I Antibody

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Polyclonal Anti-Rat IGF-1 Antibody

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Polyclonal IGF-II Antibody

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Polyclonal IL-2 Antibody

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Polyclonal IL-3 Antibody

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Polyclonal IL-7 Antibody

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Polyclonal IL-8 Antibody

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Polyclonal IL-21 Antibody

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Polyclonal IP-10 Antibody

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Polyclonal IP-10 Antibody

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Polyclonal CCR10 Antibody

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Polyclonal LIF Antibody

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Polyclonal RANKL Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RANKL . This antibody is tested and proven to work in the following applications:

Polyclonal ApoSAA Antibody

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Polyclonal TGF-alpha Antibody

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Polyclonal TGF-beta3 Antibody

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Polyclonal TNF-beta Antibody

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Polyclonal TNF-R1 Antibody

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Polyclonal CXCR4 Antibody

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Polyclonal C3aR Antibody

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Polyclonal CTGF Antibody

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Polyclonal sRANK Ligand Polyclonal Antibody

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Polyclonal MIF Antibody

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Polyclonal BMP-5 Antibody

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Polyclonal BMP-10 Antibody

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Polyclonal FGF-20 Antibody

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Polyclonal IFN alpha 2b Antibody

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Polyclonal IFN alpha Antibody

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Polyclonal IFN alpha Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IFN alpha . This antibody is tested and proven to work in the following applications:

Polyclonal HDAC8 Antibody

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Polyclonal TGF-beta Receptor I Antibody

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Polyclonal VEGF-B Antibody

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Polyclonal VEGF-D Antibody

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Polyclonal Galectin-7 Antibody

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Polyclonal TCR beta Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TCR beta . This antibody is tested and proven to work in the following applications:

Polyclonal PTHrP Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PTHrP . This antibody is tested and proven to work in the following applications:

Polyclonal RELM-beta Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RELM-beta . This antibody is tested and proven to work in the following applications:

Polyclonal BMP-2 Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMP-2 . This antibody is tested and proven to work in the following applications:

Polyclonal BMP-4 Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMP-4 . This antibody is tested and proven to work in the following applications:

Polyclonal BMP-4 Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMP-4 . This antibody is tested and proven to work in the following applications:

Polyclonal BMP-5 Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMP-5 . This antibody is tested and proven to work in the following applications:

Polyclonal BMP-6 Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMP-6 . This antibody is tested and proven to work in the following applications:

Polyclonal IGF-BP5 Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IGF-BP5 . This antibody is tested and proven to work in the following applications:

Polyclonal IL-12p40 Antibody

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Polyclonal TFF-2/Spasmolysin Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TFF-2/Spasmolysin . This antibody is tested and proven to work in the following applications:

Polyclonal Wnt-1 Antibody

APR00320G 0.1mg
EUR 484
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Polyclonal MMP-3 Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MMP-3 . This antibody is tested and proven to work in the following applications:

Polyclonal Endostatin Antibody

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Polyclonal MART-1/Melan-A Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MART-1/Melan-A . This antibody is tested and proven to work in the following applications:

Polyclonal HSP90 Antibody

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Polyclonal HSP70 antibody

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Polyclonal Placental Lactogen Antibody

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Polyclonal GDF-9 Antibody

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Polyclonal JMJD6 Antibody

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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD6 . This antibody is tested and proven to work in the following applications:

Polyclonal USP1 Antibody

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EUR 528
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Polyclonal USP2 Antibody

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Polyclonal USP25 Antibody

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Polyclonal UHRF2 Antibody

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Polyclonal BMI 1 Antibody

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Polyclonal EHMT2 Antibody

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EUR 528
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Polyclonal RBBP4 Antibody

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EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RBBP4 . This antibody is tested and proven to work in the following applications:

Polyclonal SMARCA4 Antibody

APR00336G 0.1mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SMARCA4 . This antibody is tested and proven to work in the following applications:

Polyclonal BRD4 Antibody

APR00337G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BRD4 . This antibody is tested and proven to work in the following applications:

Polyclonal IL-10 Antibody

APR00338G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-10 . This antibody is tested and proven to work in the following applications:

Polyclonal BRD4 Antibody

APR00339G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BRD4 . This antibody is tested and proven to work in the following applications:

Polyclonal BRD4 Antibody

APR00340G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BRD4 . This antibody is tested and proven to work in the following applications:

Polyclonal Heregulin-β2/Neuregulin-1 Antibody

APR00341G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Heregulin-β2/Neuregulin-1 . This antibody is tested and proven to work in the following applications:

Polyclonal Neuregulin/Heregulin-1β Antibody

APR00342G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Neuregulin/Heregulin-1β . This antibody is tested and proven to work in the following applications:

Polyclonal PSGL-1 Antibody

APR00343G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PSGL-1 . This antibody is tested and proven to work in the following applications:

Polyclonal GHBP Antibody

APR00344G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GHBP . This antibody is tested and proven to work in the following applications:

Polyclonal IL-1RA Antibody

APR00345G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-1RA . This antibody is tested and proven to work in the following applications:

Polyclonal Wnt-2 Antibody

APR00346G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Wnt-2 . This antibody is tested and proven to work in the following applications:

Polyclonal TDRD4 Antibody

APR00347G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TDRD4 . This antibody is tested and proven to work in the following applications:

Polyclonal Procathepsin B Antibody

APR00348G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Procathepsin B . This antibody is tested and proven to work in the following applications:

Polyclonal PEDF Antibody

APR00349G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PEDF . This antibody is tested and proven to work in the following applications:

Polyclonal IFN-alpha 2a Antibody

APR00350G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IFN-alpha 2a . This antibody is tested and proven to work in the following applications:

Polyclonal FGF-4 Antibody

APR00351G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF-4 . This antibody is tested and proven to work in the following applications:

Polyclonal Granzyme A Antibody

APR00352G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Granzyme A . This antibody is tested and proven to work in the following applications:

Polyclonal Cathepsin S Antibody

APR00353G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Cathepsin S . This antibody is tested and proven to work in the following applications:

Polyclonal TDP2 Antibody

APR00354G 0.05mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TDP2 . This antibody is tested and proven to work in the following applications:

Polyclonal CCL4 Antibody (Center)

APR00355G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CCL4 (Center). This antibody is tested and proven to work in the following applications:

Polyclonal CD-14 Antibody (CT)

APR00356G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CD-14 (CT). This antibody is tested and proven to work in the following applications:

Polyclonal CD-14 Antibody (NT)

APR00357G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CD-14 (NT). This antibody is tested and proven to work in the following applications:

Polyclonal CD-45 Antibody (CT)

APR00358G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CD-45 (CT). This antibody is tested and proven to work in the following applications:

Polyclonal ANGPT2 Antibody (CT)

APR00359G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ANGPT2 (CT). This antibody is tested and proven to work in the following applications:

Polyclonal ANGPTL1 Antibody (NT)

APR00360G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ANGPTL1 (NT). This antibody is tested and proven to work in the following applications:

Polyclonal OCT4 (OCT3) Antibody

APR00361G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human OCT4 (OCT3) . This antibody is tested and proven to work in the following applications:

Polyclonal BMPR2 Antibody (NT)

APR00362G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMPR2 (NT). This antibody is tested and proven to work in the following applications:

Polyclonal VCAM-1/CD106 Antibody (Center)

APR00364G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human VCAM-1/CD106 (Center). This antibody is tested and proven to work in the following applications:

Polyclonal TERT Antibody

APR00365G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TERT . This antibody is tested and proven to work in the following applications:

Polyclonal CD34 Antibody (Center)

APR00366G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CD34 (Center). This antibody is tested and proven to work in the following applications:

Polyclonal CD105/Endoglin Antibody (Center E395)

APR00367G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CD105/Endoglin (Center E395). This antibody is tested and proven to work in the following applications:

Polyclonal CD146/MCAM Antibody (CT)

APR00368G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CD146/MCAM (CT). This antibody is tested and proven to work in the following applications:

Polyclonal CD73/NT5E Antibody (CT)

APR00369G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CD73/NT5E (CT). This antibody is tested and proven to work in the following applications:

Polyclonal RARA polyclonal antibody

APR00370G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RARA polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal Runx1/AML1-ETO polyclonal antibody

APR00371G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Runx1/AML1-ETO polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal ETO polyclonal antibody

APR00372G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ETO polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal EzH2 polyclonal antibody

APR00373G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human EzH2 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal BRD2 polyclonal antibody

APR00374G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BRD2 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal JMJD2c polyclonal antibody

APR00375G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD2c polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal BMI1 polyclonal antibody

APR00376G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMI1 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal PD-1/PDCD1 Antibody

APR00377G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PD-1/PDCD1 . This antibody is tested and proven to work in the following applications:

Polyclonal Cyclin E1 Antibody

APR00378G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Cyclin E1 . This antibody is tested and proven to work in the following applications:

Polyclonal Cyclin F Antibody

APR00379G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Cyclin F . This antibody is tested and proven to work in the following applications:

Polyclonal Cyclin G1 Antibody

APR00380G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Cyclin G1 . This antibody is tested and proven to work in the following applications:

Polyclonal CD1e Antibody

APR00381G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CD1e . This antibody is tested and proven to work in the following applications:

Polyclonal CD3d Antibody

APR00382G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CD3d . This antibody is tested and proven to work in the following applications:

Polyclonal CD4 Antibody

APR00383G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CD4 . This antibody is tested and proven to work in the following applications:

Polyclonal CD9 Antibody

APR00384G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CD9 . This antibody is tested and proven to work in the following applications:

Polyclonal CD58 Antibody

APR00385G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CD58 . This antibody is tested and proven to work in the following applications:

Polyclonal Plasmin Antibody

APR00386G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Plasmin . This antibody is tested and proven to work in the following applications:

Polyclonal P-glycoprotein Antibody

APR00387G 0.1mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human P-glycoprotein . This antibody is tested and proven to work in the following applications:

Polyclonal TRAIL Antibody

APR00388G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TRAIL . This antibody is tested and proven to work in the following applications:

Polyclonal PI3Kβ Antibody

APR00389G 0.1mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PI3Kβ . This antibody is tested and proven to work in the following applications:

Polyclonal PI3Kβ Antibody

APR00390G 0.1mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PI3Kβ . This antibody is tested and proven to work in the following applications:

Polyclonal Survivin Antibody

APR00391G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Survivin . This antibody is tested and proven to work in the following applications:

Polyclonal Survivin Antibody

APR00392G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Survivin . This antibody is tested and proven to work in the following applications:

Polyclonal PAK1 Antibody

APR00393G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PAK1 . This antibody is tested and proven to work in the following applications:

Polyclonal BCMA (TNFRSF17) Antibody

APR00394G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BCMA (TNFRSF17) . This antibody is tested and proven to work in the following applications:

Polyclonal RbBP5 Antibody

APR00395G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RbBP5 . This antibody is tested and proven to work in the following applications:

Polyclonal RbBP5 Antibody

APR00396G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RbBP5 . This antibody is tested and proven to work in the following applications:

Polyclonal PAK1 Antibody

APR00397G 0.1mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PAK1 . This antibody is tested and proven to work in the following applications:

Polyclonal MMP-9 Antibody

APR00398G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MMP-9 . This antibody is tested and proven to work in the following applications:

Polyclonal IL-13 Antibody

APR00399G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-13 . This antibody is tested and proven to work in the following applications:

Polyclonal IL-13 Antibody

APR00400G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-13 . This antibody is tested and proven to work in the following applications:

Polyclonal IL-13 Antibody

APR00401G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-13 . This antibody is tested and proven to work in the following applications:

Polyclonal M-CSF Antibody

APR00402G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human M-CSF . This antibody is tested and proven to work in the following applications:

Polyclonal M-CSF Antibody

APR00403G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human M-CSF . This antibody is tested and proven to work in the following applications:

Polyclonal MIP-2 Antibody

APR00404G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MIP-2 . This antibody is tested and proven to work in the following applications:

Polyclonal MIP-2 Antibody

APR00405G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MIP-2 . This antibody is tested and proven to work in the following applications:

Polyclonal SCF Antibody

APR00406G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SCF . This antibody is tested and proven to work in the following applications:

Polyclonal SCF Antibody

APR00407G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SCF . This antibody is tested and proven to work in the following applications:

Polyclonal SCF Antibody

APR00408G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SCF . This antibody is tested and proven to work in the following applications:

Familial dilated cardiomyopathy introduced on by a novel variant inside the Lamin A/C gene: a case report

Background: Familial dilated cardiomyopathy (FDCM) is usually inherited as an autosomal dominant trait. The Lamin A/C (LMNA) gene variants have been acknowledged to be associated to DCM, conductive system issues, variety 2 Emery-Dreifuss muscular dystrophy and plenty of different completely different issues. Proper right here, we reported a novel variant inside the LMNA gene that’s more likely to be related to FDCM.

Case presentation: A 30-year-old youthful man was hospitalized for chest tightness, extreme fatigue, palpitation and impaired train tolerance. He had scientific traits along with cardiac dilatation, atrial tachyarrhythmia, excessive conductive system issues, and dyskinesia of every greater limbs and the neck.

Genetic sequence analysis indicated that the affected particular person carried a novel c.1325 T>C heterozygous LMNA gene variant. Catheter ablation and cardiac resynchronization treatment with pacing carry out (CRT-P) have been carried out to take care of the arrhythmia.

 

Conclusion: The variant c.1325 T>C is a novel variant inside the LMNA gene that has not been beforehand reported. Youthful victims with DCM, conductive system issues and skeletal myopathy should be alert to the potential for LMNA gene variant.

Cardiac resynchronization treatment (CRT) is also an reasonably priced choice for affected particular person carrying a LMNA gene variant with third-degree atrioventricular block even when the left ventricular ejection fraction is preserved with the intention to cease the deterioration of cardiac carry out introduced on by correct ventricular pacing dependency.

Genetic analysis of children with congenital ocular anomalies in three ecological areas of Nepal: a piece II of Nepal pediatric ocular sicknesses analysis

Background: Genetic eye sicknesses characterize a giant and heterogeneous group of childhood ocular morbidity. Explicit particular person sicknesses may set off plenty of structural anomalies and developmental choices.

Nepal Pediatric Ocular Sickness Analysis (NPODS) was a population-based epidemiological analysis carried out all through three ecological areas of Nepal to search out out the prevalence and etiology of childhood ocular morbidity and blindness. In Half II of this analysis, genetic analysis was carried out for teenagers who’ve been found to have congenital ocular anomalies.

Methodology: It was a cross sectional descriptive analysis. An entire of 10,270 children all through three completely completely different ecological areas in Nepal (Low lands, hills, and mountains) underwent ocular examinations in NPODS. Out of 374 (3.6%) of children with ocular abnormalities, 30 have been thought of congenital in nature. Centered genetic analysis, along with genotyping for genes explicit to presenting phenotype, was carried out for 25 children using serum samples.

Outcomes: Out of 25 children, 18 had vital genetic outcomes. Analysis revealed one missense alteration G12411T of Zinc Finger Homeobox 4 (ZFHX4) gene in a single participant amongst 10 with congenital ptosis and one different missense variation T > C P. Y374 C of Signaling Receptor and Transporter Retinol 6 (STRA6) gene in a single participant amongst Three with microphthalmos.

Conclusion: The analysis is first of its type from Nepal and mutant genes have been distinctive to Nepalese Inhabitants. Further analysis of genetic elements is important to greater understand genetic affiliation with ocular sicknesses and conditions. This helps extra in genetic counseling and likely gene treatment to forestall blindness from these conditions.

Identification of diagnostic and prognostic biomarkers, and candidate targeted brokers for hepatitis B virus-associated early stage hepatocellular carcinoma based mostly totally on RNA-sequencing info

  • Main liver most cancers is a shortly progressing neoplasm with extreme morbidity and mortality expenses. The present analysis aimed to find out potential diagnostic and prognostic biomarkers, and candidate targeted brokers for hepatitis B virus (HBV)-associated early stage hepatocellular carcinoma (HCC). The gene expression profiles had been extracted from the Gene Expression Omnibus database.
  • Differentially expressed genes (DEGs), hub genes and the enrichment of signaling pathways had been filtered out by means of a high-throughput sequencing method. The affiliation between hub genes and the outcomes of the irregular expression of hub genes on the velocity of genetic variation, whole survival (OS), relapse-free survival (RFS), progression-free survival (PFS) and disease-free survival (DSS) of victims with HCC, along with pathological stage and grade, had been analyzed using fully completely different databases. An entire of 1,582 DEGs had been acknowledged.
  • Gene Ontology analysis revealed that the DEGs had been primarily involved inside the ‘oxidation-reduction course of’, ‘steroid metabolic course of’, ‘metabolic course of’ and ‘fatty acid beta-oxidation’. Enrichment analysis of Kyoto Encyclopedia of Genes and Genomes pathways revealed that the DEGs had been primarily associated to ‘metabolic pathways’, ‘PPAR signaling pathway’, ‘fatty acid degradation’ and the ‘cell cycle’.
  • An entire of Eight hub genes had been extracted. Furthermore, the irregular expression ranges of hub genes had been intently associated to the OS, RFS, PFS and DSS of victims, the pathological stage and the grade. Furthermore, irregular expression ranges of the Eight hub genes had been current in >30% of all samples.
  • Plenty of small molecular compounds which is able to reverse the altered DEGs had been acknowledged based mostly totally on Connectivity Map analysis, along with phenoxybenzamine, GW-8510, resveratrol, 0175029-0000 and daunorubicin. In conclusion, the dysfunction of fat metabolic pathways, the cell cycle, oxidation-reduction processes and viral carcinogenesis would possibly serve very important roles inside the incidence of HBV-associated early stage HCC. The acknowledged Eight hub genes would possibly act as robust biomarkers for prognosis and prognosis. Some small molecular compounds is also promising targeted brokers in opposition to HBV-associated early stage HCC.

Doxorubicin hydrochloride

ADC-P-014 unit Ask for price

Doxorubicin (hydrochloride)

HY-15142 100mg
EUR 147

Doxorubicin hydrochloride

GA4969-100MG 100 mg
EUR 181

Doxorubicin hydrochloride

GA4969-10MG 10 mg
EUR 78

Doxorubicin hydrochloride

GA4969-25MG 25 mg
EUR 98

Doxorubicin hydrochloride

GA4969-50MG 50 mg
EUR 126

Doxorubicin hydrochloride

TNC00267 20mg Ask for price

Doxorubicin hydrochloride USP

D005-10MG 10 mg
EUR 166

Doxorubicin hydrochloride USP

D005-25MG 25 mg
EUR 301

Doxorubicin Hydrochloride (Autophagy inducer)

SIH-390-10MG 10 mg
EUR 193
  • Doxorubicin Hydrochloride is used in a clinical setting for the treatment of a wide range of cancers, including lymphomas, leukemias, and solid tumors of the breast, pancreas, stomach, bladder, and ovaries. This drug intercalates into DNA and therefo
  • Show more
Description: The substance Doxorubicin Hydrochloride is a autophagy inducer. It is synthetically produced and has a purity of >98%. The pure substance is red solid which is soluble in water (50 mM)..

Doxorubicin Hydrochloride (Autophagy inducer)

SIH-390-50MG 50 mg
EUR 529
  • Doxorubicin Hydrochloride is used in a clinical setting for the treatment of a wide range of cancers, including lymphomas, leukemias, and solid tumors of the breast, pancreas, stomach, bladder, and ovaries. This drug intercalates into DNA and therefo
  • Show more
Description: The substance Doxorubicin Hydrochloride is a autophagy inducer. It is synthetically produced and has a purity of >98%. The pure substance is red solid which is soluble in water (50 mM)..

Erlotinib, Hydrochloride Salt

1588-100
EUR 169

Erlotinib, Hydrochloride Salt

1588-1000
EUR 398

Doxorubicin

D063-100MG 100 mg
EUR 1051

Doxorubicin

D063-25MG 25 mg
EUR 322

Doxorubicin

abx188695-1g 1 g
EUR 467
  • Shipped within 1-2 weeks.

Doxorubicin

ADC-P-013 unit Ask for price

Doxorubicin

A3966-10 10 mg
EUR 108
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin

A3966-100 100 mg
EUR 235
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin

A3966-25 25 mg
EUR 131
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin

A3966-5.1 10 mM (in 1mL DMSO)
EUR 131
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin

A3966-S Evaluation Sample
EUR 81
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin

HY-15142A 100mg
EUR 215

Erlotinib, Hydrochloride Salt, >99%

BC026-101 1g
EUR 273

Erlotinib, Hydrochloride Salt, >99%

BC026-102 2g
EUR 388

Erlotinib, Hydrochloride Salt, >99%

BC026-105 5g
EUR 570

Doxorubicin HCl

20-abx184016
  • EUR 746.00
  • EUR 1483.00
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.

Adriamycin (Doxorubicin)

E1KS1208 10mg
EUR 409

Doxorubicin 10mM

TG4120 0.25ml
EUR 156

17-DMAG, Hydrochloride Salt, >98%

BC024-001 1mg
EUR 178

17-DMAG, Hydrochloride Salt, >98%

BC024-005 5mg
EUR 286

17-DMAG, Hydrochloride Salt, >98%

BC024-010 10mg
EUR 408

17-DMAG, Hydrochloride Salt, >98%

BC024-025 25mg Ask for price

17-DMAG, Hydrochloride Salt, >99%

BC024-100 100mg Ask for price

17-DMAG, Hydrochloride Salt, >99%

BC024-101 1g Ask for price

17-DMAG, Hydrochloride Salt, >99%

BC024-250 250mg Ask for price

OSU-03012, Hydrochloride Salt, >98%

BC061-005 5mg
EUR 313

OSU-03012, Hydrochloride Salt, >98%

BC061-025 25mg
EUR 529

Doxorubicin (Adriamycin) HCl

A1832-10 10 mg
EUR 125
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin (Adriamycin) HCl

A1832-100 100 mg
EUR 467
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin (Adriamycin) HCl

A1832-25 25 mg
EUR 189
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin (Adriamycin) HCl

A1832-5.1 10 mM (in 1mL DMSO)
EUR 113
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin HCl, 100mg

R2531-100mg
EUR 1300

Doxorubicin HCl, 10mg

R2531-10mg
EUR 197

Anti-EGFR-doxorubicin ADC

ADC-W-600 1mg Ask for price
Description: This ADC product is comprised of an anti-EGFR monoclonal antibody conjugated via a linker to a doxorubicin

Anti-CD22-DIBO-doxorubicin ADC

ADC-W-339 1mg Ask for price
Description: This ADC product is comprised of an anti-CD22 monoclonal antibody conjugated via a DIBO linker to a doxorubicin

Anti-TNFRSF8 (cAC10)-DIBO-doxorubicin ADC

ADC-W-406 1mg Ask for price
Description: This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (cAC10) conjugated via a DIBO linker to a doxorubicin

Anti-ERBB2 (Trastuzumab)-NGM-doxorubicin ADC

ADC-W-412 1mg Ask for price
Description: This ADC product is comprised of an anti-ERBB2 monoclonal antibody conjugated via a NGM linker to adoxorubicin

Anti-EGFR (cetuximab)-SMCC-Doxorubicin ADC

ADC-W-504 1mg Ask for price
Description: This ADC product is comprised of an anti-EGFR monoclonal antibody (cetuximab) conjugated via a SMCC linker to Doxorubicin

Anti-EpCAM (MOC31)-hydrazone-Doxorubicin ADC

ADC-W-581 1mg Ask for price
Description: This ADC product is comprised of an anti-EPCAM monoclonal antibody (MOC31) conjugated via a hydrazone linker to Doxorubicin

Anti-FUT3 (clone cBR96)-hydrazone-doxorubicin ADC

ADC-W-423 1mg Ask for price
Description: This ADC product is comprised of an anti-FUT3 monoclonal antibody (clone cBR96) conjugated via a hydrazone linker to adoxorubicin

Anti-CD70 (clone h1F6)-β-glucuronide-doxorubicin ADC

ADC-W-376 1mg Ask for price
Description: This ADC product is comprised of an anti-CD70 monoclonal antibody (clone h1F6) conjugated via a β-glucuronide linker to a doxorubicin

Bile salt

BB0225 25g
EUR 79.58
  • Product category: Biochemicals/Detergents/Surfactants

Anti-TNFRSF8 (cCA10)-β-glucuronide-doxorubicin propyloxazoline (DPO) ADC

ADC-W-353 1mg Ask for price
Description: This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (cCA10) conjugated via a β-glucuronide linker to a doxorubicin propyloxazoline (DPO)

Human HeLa (Cervix Adenocarcinoma) Cell Nuclear Extract - Doxorubicin Stimulated

HCL-2004 100ug
EUR 225

Human HeLa (Cervix Adenocarcinoma) Whole Cell Lysate - Doxorubicin Stimulated

HCL-2010 100ug
EUR 213

TAME Hydrochloride

2050-100
EUR 126

TAME Hydrochloride

2050-1000
EUR 479

TAME Hydrochloride

2050-500
EUR 338

Verapamil hydrochloride

2861-1G
EUR 131

Verapamil hydrochloride

2861-5G
EUR 327

Ticlopidine hydrochloride

2919-25
EUR 403

Ticlopidine hydrochloride

2919-5
EUR 153

EHNA hydrochloride

2265-25
EUR 283

EHNA hydrochloride

2265-5
EUR 115

AdipoRon hydrochloride

2572-25
EUR 588

AdipoRon hydrochloride

2572-5
EUR 185

Pargyline hydrochloride

2618-1000
EUR 175

Pargyline hydrochloride

2618-500
EUR 120

Clorgyline hydrochloride

2622-10
EUR 120

Clorgyline hydrochloride

2622-50
EUR 327

Clindamycin hydrochloride

2627-10
EUR 131

Clindamycin hydrochloride

2627-50
EUR 370

Loperamide hydrochloride

2683-1000
EUR 185

Loperamide hydrochloride

2683-500
EUR 131

Clonidine hydrochloride

2684-100
EUR 131

Clonidine hydrochloride

2684-500
EUR 359

Leelamine hydrochloride

2717-25
EUR 457

Leelamine hydrochloride

2717-5
EUR 153

SBE13 hydrochloride

2847-10
EUR 185

SBE13 hydrochloride

2847-50
EUR 588

Amodiaquine hydrochloride

A085-5G 5 g
EUR 55

Metformin, Hydrochloride

1691-5G
EUR 158

Irinotecan Hydrochloride

1752-250
EUR 387

Irinotecan Hydrochloride

1752-50
EUR 147

Epirubicin Hydrochloride

1753-25
EUR 457

Epirubicin Hydrochloride

1753-5
EUR 158

Gemcitabine Hydrochloride

1759-100
EUR 370

Gemcitabine Hydrochloride

1759-25
EUR 156

Amiodarone Hydrochloride

1828-100
EUR 126

Amiodarone Hydrochloride

1828-500
EUR 338

Phenformin hydrochloride

1889-100
EUR 115

Phenformin hydrochloride

1889-1000
EUR 359

Tomatidine hydrochloride

1893-25
EUR 137

Vancomycin Hydrochloride

B1507-1G
EUR 153

Vancomycin Hydrochloride

B1507-250
EUR 120

Vancomycin Hydrochloride

B1507-5G
EUR 262

Lincomycin Hydrochloride

B1524-1G
EUR 142

Lincomycin Hydrochloride

B1524-5G
EUR 403

Minocycline Hydrochloride

B1525-250
EUR 414

Minocycline Hydrochloride

B1525-50
EUR 142

Oxytetracycline Hydrochloride

B1527-25G
EUR 229

Oxytetracycline Hydrochloride

B1527-5G
EUR 109

Tetracycline Hydrochloride

B1535-10G
EUR 109

Tetracycline Hydrochloride

B1535-50G
EUR 196

Hydroxyfasudil Hydrochloride

B1559-25
EUR 631

Hydroxyfasudil Hydrochloride

B1559-5
EUR 196

Thioridazine Hydrochloride

B1581-1G
EUR 120

Thioridazine Hydrochloride

B1581-5G
EUR 327

Ivabradine Hydrochloride

B1595-10
EUR 142

Bendamustine Hydrochloride

B1596-25
EUR 457

Bendamustine Hydrochloride

B1596-5
EUR 153

Afuresertib hydrochloride

B1848-5
EUR 175

Chlorpromazine hydrochloride

B1992-100
EUR 120

Chlorpromazine hydrochloride

B1992-500
EUR 294

Triflupromazine hydrochloride

B1993-100
EUR 120

 ZLN024 hydrochloride

B2034-25
EUR 588

 ZLN024 hydrochloride

B2034-5
EUR 185

Topotecan hydrochloride

B2050-10
EUR 131

Givinostat hydrochloride

B2081-25
EUR 756

Givinostat hydrochloride

B2081-5
EUR 229

Moexipril hydrochloride

B2134-25
EUR 294

Imidapril hydrochloride

B2135-25
EUR 414

Imidapril hydrochloride

B2135-5
EUR 142

Benazepril hydrochloride

B2138-250
EUR 294

Benazepril hydrochloride

B2138-50
EUR 131

Dorzolamide hydrochloride

B2185-10
EUR 120

Dorzolamide hydrochloride

B2185-50
EUR 327

Eltoprazine hydrochloride

B2301-25
EUR 457

Eltoprazine hydrochloride

B2301-5
EUR 153

Papaverine hydrochloride

B2315-250
EUR 262

Papaverine hydrochloride

B2315-50
EUR 120

Sarecycline hydrochloride

B2383-25
EUR 588

Sarecycline hydrochloride

B2383-5
EUR 185

Sertraline (hydrochloride)

B2393-10
EUR 131

Sertraline (hydrochloride)

B2393-50
EUR 327

Migalastat hydrochloride

B2404-25
EUR 756

Migalastat hydrochloride

B2404-5
EUR 229

Butenafine hydrochloride

B2421-250
EUR 327

Butenafine hydrochloride

B2421-50
EUR 120

Naftifine hydrochloride

B2422-10
EUR 131

Naftifine hydrochloride

B2422-50
EUR 349

Rilpivirine hydrochloride

B2427-25
EUR 414

Rilpivirine hydrochloride

B2427-5
EUR 142

Tirabrutinib hydrochloride

B2556-25
EUR 457

Tirabrutinib hydrochloride

B2556-5
EUR 153

Robenidine hydrochloride

B2560-1G
EUR 131

Robenidine hydrochloride

B2560-5G
EUR 262

Sardomozide Hydrochloride

B2566-25
EUR 631

Sardomozide Hydrochloride

B2566-5
EUR 196

Riviciclib hydrochloride

B2567-1
EUR 142

Riviciclib hydrochloride

B2567-5
EUR 414

CPTH2 (hydrochloride)

B2815-1
EUR 120

CPTH2 (hydrochloride)

B2815-5
EUR 294

Resminostat (hydrochloride)

B2852-25
EUR 588

Resminostat (hydrochloride)

B2852-5
EUR 185

Almorexant hydrochloride

B3241-10 10 mg
EUR 440
Description: Almorexant is an antagonist of Orexin 1 receptor (OX1R) and Orexin 2 receptor (OX2R) with Kd values of 1.3nM and 0.17nM, respectively [1].

Almorexant hydrochloride

B3241-5 5 mg
EUR 270
Description: Almorexant is an antagonist of Orexin 1 receptor (OX1R) and Orexin 2 receptor (OX2R) with Kd values of 1.3nM and 0.17nM, respectively [1].

Memantine hydrochloride

B3308-200 200 mg
EUR 137
Description: Memantine hydrochloride is an antagonist of NMDA receptor with IC50 values of 0.93?M, 0.82?M and 0.47?M for NRIa/NR2A, NRIa/NR2B and NRIa/NR2D, respectively [1].

Memantine hydrochloride

B3308-5.1 10 mM (in 1mL DMSO)
EUR 113
Description: Memantine hydrochloride is an antagonist of NMDA receptor with IC50 values of 0.93?M, 0.82?M and 0.47?M for NRIa/NR2A, NRIa/NR2B and NRIa/NR2D, respectively [1].

Memantine hydrochloride

B3308-S Evaluation Sample
EUR 81
Description: Memantine hydrochloride is an antagonist of NMDA receptor with IC50 values of 0.93?M, 0.82?M and 0.47?M for NRIa/NR2A, NRIa/NR2B and NRIa/NR2D, respectively [1].

Cyproheptadine hydrochloride

B3309-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Cyproheptadine hydrochloride is an antagonist of serotonin receptor [1]. Cyproheptadine is a serotonin and histamine antagonist as well as an antimuscarinic reagent.

Cyproheptadine hydrochloride

B3309-50 50 mg
EUR 128
Description: Cyproheptadine hydrochloride is an antagonist of serotonin receptor [1]. Cyproheptadine is a serotonin and histamine antagonist as well as an antimuscarinic reagent.

Cyproheptadine hydrochloride

B3309-S Evaluation Sample
EUR 81
Description: Cyproheptadine hydrochloride is an antagonist of serotonin receptor [1]. Cyproheptadine is a serotonin and histamine antagonist as well as an antimuscarinic reagent.

Moxonidine hydrochloride

B3314-10 10 mg
EUR 195
Description: Moxonidine hydrochloride is a mixed agonist of ?2-adrenergic receptor (?2AR) and imidazoline-1 receptor(I1R) with Ki values of 4.2±3.2 nmol/L, 13.0±4.2 nmol/L.

Moxonidine hydrochloride

B3314-100 100 mg
EUR 864
Description: Moxonidine hydrochloride is a mixed agonist of ?2-adrenergic receptor (?2AR) and imidazoline-1 receptor(I1R) with Ki values of 4.2±3.2 nmol/L, 13.0±4.2 nmol/L.

Moxonidine hydrochloride

B3314-50 50 mg
EUR 502
Description: Moxonidine hydrochloride is a mixed agonist of ?2-adrenergic receptor (?2AR) and imidazoline-1 receptor(I1R) with Ki values of 4.2±3.2 nmol/L, 13.0±4.2 nmol/L.

Bupropion hydrochloride

B3326-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Bupropion hydrochloride is a dual effective inhibitor of norepinephrine and dopamine neurotransmitter with the IC50 values of 6.5 ± 0.6?M and 3.4 ± 0.4 ?M, respectively [1].

Bupropion hydrochloride

B3326-50 50 mg
EUR 128
Description: Bupropion hydrochloride is a dual effective inhibitor of norepinephrine and dopamine neurotransmitter with the IC50 values of 6.5 ± 0.6?M and 3.4 ± 0.4 ?M, respectively [1].

Bupropion hydrochloride

B3326-S Evaluation Sample
EUR 81
Description: Bupropion hydrochloride is a dual effective inhibitor of norepinephrine and dopamine neurotransmitter with the IC50 values of 6.5 ± 0.6?M and 3.4 ± 0.4 ?M, respectively [1].

Sotalol hydrochloride

B3341-100 100 mg
EUR 139
Description: Sotalol hydrochloride is a potent and non-selective antagonist of ?-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1].

Sotalol hydrochloride

B3341-200 200 mg
EUR 187
Description: Sotalol hydrochloride is a potent and non-selective antagonist of ?-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1].

Sotalol hydrochloride

B3341-5.1 10 mM (in 1mL DMSO)
EUR 119
Description: Sotalol hydrochloride is a potent and non-selective antagonist of ?-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1].

Sotalol hydrochloride

B3341-50 50 mg
EUR 106
Description: Sotalol hydrochloride is a potent and non-selective antagonist of ?-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1].

Sotalol hydrochloride

B3341-S Evaluation Sample
EUR 81
Description: Sotalol hydrochloride is a potent and non-selective antagonist of ?-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1].

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