Familial dilated cardiomyopathy brought on by a novel variant
Subsequent era sequencing reveals a novel pathogenic variant within the ATMgene
Introduction: Ataxia telangiectasia (A-T) is a unusual autosomal recessive multisystemic sickness. Victims with the A-T syndrome present a broad spectrum of sickness phenotypes. The ATM (ataxia telangiectasia mutated) gene, the one causative gene for A-T.
Methodology: A affected particular person of Persian origin presenting with typical A-T was referred to our genetics center for specialised genetic counseling and testing. Centered next-generation sequencing (NGS) was utilized. Sanger sequencing was used to substantiate the candidate variant. Modeling was carried out using the SWISS-MODEL server.Outcomes: A homozygous stop-gain variant c.829G > T (p.E277*) was found inside the ATM gene. This variant was confirmed by Sanger sequencing and modeling of native building and truncated building was carried out.
Conclusion: Up to now, just a few pathogenic variants of the ATM gene have been reported from the Iranian inhabitants. The discovering has implications in molecular diagnostic for A-T in Iran.
 EC MEDIUM |
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) MB protein (His tag) |
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Description: Purified recombinant Human MB protein |
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Description: Purified recombinant Human MAP1LC3B protein |
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| 80R-1636 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human RAB7A protein |
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| 80R-1637 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant E.coli Ecotin protein |
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| 80R-1638 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human AIF1L protein |
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Description: Purified recombinant Human AK4 protein |
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Description: Purified recombinant Human BDH2 protein |
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| 80R-1641 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human BPNT1 protein |
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Description: Purified recombinant Human DCUN1D1 protein |
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Description: Purified recombinant Human GABARAPL2 protein |
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| 80R-1645 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human GGCT protein |
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| 80R-1646 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human GRAP2 protein |
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Description: Purified recombinant Human NME3 protein |
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Description: Purified recombinant Human NUDT2 protein |
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| 80R-1649 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human RAP1B protein |
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| 80R-1650 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human TXNL1 protein |
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| 80R-1651 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human PFDN4 protein |
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| 80R-1652 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human UBE2K protein |
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| 80R-1653 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human NCALD protein |
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| 80R-1654 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human DDIT4 protein |
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| 80R-1655 | Fitzgerald | 10 ug | EUR 305 |
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Description: Purified recombinant Human TFAM protein |
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| 80R-1656 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human TAF9 protein |
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| 80R-1657 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human SUGT1 protein |
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Description: Purified recombinant Human RAB1A protein |
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Description: Purified recombinant Human PPP3R1 protein |
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Description: Purified recombinant Human EIF1AY protein |
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Description: Purified recombinant Human ATG5 protein |
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Description: Purified recombinant Human FADH1 protein |
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Description: Purified recombinant Human PEF1 protein |
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Description: Purified recombinant Human MLF1 protein |
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Description: Purified recombinant Human RAB21 protein |
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Description: Purified recombinant Human LCN2 protein |
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| 80R-1667 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human CIB2 protein |
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Description: Purified recombinant Human NMT2 protein |
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| 80R-1669 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human DNAJC19 protein |
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| 80R-1670 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant mouse DHFR protein |
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Description: Purified recombinant Human IMPA2 protein |
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Description: Purified recombinant Human BCAS2 protein |
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| 80R-1673 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human BLNK protein |
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| 80R-1674 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human CCL3L1 protein |
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| 80R-1675 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human CCL20 protein |
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| 80R-1676 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human RAB6B protein |
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| 80R-1677 | Fitzgerald | 10 ug | EUR 305 |
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Description: Purified recombinant Human SNRPE protein |
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| 80R-1678 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human SF3B14 protein |
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| 80R-1679 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human RERG protein |
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) NUDT3 protein (His tag) |
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| 80R-1680 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human NUDT3 protein |
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) MYL9 protein (His tag) |
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| 80R-1681 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human MYL9 protein |
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| 80R-1682 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human CAPS protein |
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| 80R-1683 | Fitzgerald | 10 ug | EUR 305 |
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Description: Purified recombinant Human RPS14 protein |
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) LYPLA2 protein (His tag) |
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| 80R-1684 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human LYPLA2 protein |
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) ENOPH1 protein (His tag) |
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| 80R-1685 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human ENOPH1 protein |
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) ACYP1 protein (His tag) |
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| 80R-1686 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human ACYP1 protein |
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) BATF protein (His tag) |
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| 80R-1687 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human BATF protein |
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) CCL14 protein (His tag) |
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| 80R-1688 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human CCL14 protein |
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) eFIMC protein (His tag) |
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| 80R-1689 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant E.coli eFIMC protein |
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) ERH protein (His tag) |
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| 80R-1690 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human ERH protein |
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) MESDC2 protein (His tag) |
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| 80R-1691 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human MESDC2 protein |
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) NUDT16L1 protein (His tag) |
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| 80R-1692 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human NUDT16L1 protein |
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) NUDT21 protein (His tag) |
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| 80R-1693 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human NUDT21 protein |
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) RBP7 protein (His tag) |
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| 80R-1694 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human RBP7 protein |
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) SNRPD2 protein (His tag) |
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| 80R-1695 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human SNRPD2 protein |
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) TAGLN2 protein (His tag) |
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| 80R-1696 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human TAGLN2 protein |
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) TDO2 protein (His tag) |
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| 80R-1697 | Fitzgerald | 10 ug | EUR 305 |
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Description: Purified recombinant Human TDO2 protein |
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) UFM1 protein (His tag) |
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| 80R-1698 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human UFM1 protein |
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) SRI protein (His tag) |
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| 80R-1699 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human SRI protein |
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) Beta Lactamase protein (His tag) |
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| 80R-1700 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant E.coli Beta Lactamase protein |
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) HDHD3 protein (His tag) |
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| 80R-1701 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human HDHD3 protein |
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) BCKDHA protein (His tag) |
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| 80R-1702 | Fitzgerald | 10 ug | EUR 305 |
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Description: Purified recombinant Human BCKDHA protein |
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) CDC25A protein (His tag) |
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| 80R-1703 | Fitzgerald | 10 ug | EUR 305 |
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Description: Purified recombinant Human CDC25A protein |
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) EEF1B2 protein (His tag) |
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| 80R-1704 | Fitzgerald | 10 ug | EUR 305 |
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Description: Purified recombinant Human EEF1B2 protein |
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) CCL1 protein (His tag) |
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| 80R-1705 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human CCL1 protein |
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) KDSR protein (His tag) |
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| 80R-1706 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human KDSR protein |
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) S100A2 protein (His tag) |
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| 80R-1707 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human S100A2 protein |
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) TSTD1 protein (His tag) |
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| 80R-1708 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human TSTD1 protein |
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) MSRB3 protein (His tag) |
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| 80R-1709 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human MSRB3 protein |
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) BAG2 protein (His tag) |
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| 80R-1710 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human BAG2 protein |
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) AKR1D1 protein (His tag) |
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| 80R-1711 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human AKR1D1 protein |
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) AES protein (His tag) |
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| 80R-1712 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human AES protein |
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) EEF1D protein (His tag) |
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| 80R-1713 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human EEF1D protein |
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) MYL6 protein (His tag) |
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| 80R-1714 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human MYL6 protein |
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) S100A5 protein (His tag) |
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| 80R-1715 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human S100A5 protein |
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) S100A10 protein (His tag) |
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| 80R-1716 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human S100A10 protein |
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) A2LD1 protein (His tag) |
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| 80R-1717 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human A2LD1 protein |
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) c-Jun protein (His tag) |
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| 80R-1718 | Fitzgerald | 10 ug | EUR 305 |
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Description: Purified recombinant Human cJun protein |
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) CLIC4 protein (His tag) |
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| 80R-1719 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human CLIC4 protein |
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) DYNLRB2 protein (His tag) |
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| 80R-1720 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human DYNLRB2 protein |
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) EIF1B protein (His tag) |
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| 80R-1721 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human EIF1B protein |
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) EIF4EBP2 protein (His tag) |
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| 80R-1722 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human EIF4EBP2 protein |
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) HNRNPC protein (His tag) |
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| 80R-1723 | Fitzgerald | 10 ug | EUR 305 |
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Description: Purified recombinant Human HNRNPC protein |
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) PFDN6 protein (His tag) |
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| 80R-1724 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human PFDN6 protein |
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) S100A6 protein (His tag) |
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| 80R-1725 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human S100A6 protein |
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) S100A11 protein (His tag) |
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| 80R-1726 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human S100A11 protein |
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) S100A14 protein (His tag) |
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| 80R-1727 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human S100A14 protein |
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) TREX2 protein (His tag) |
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| 80R-1728 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human TREX2 protein |
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) HSPA13 protein (His tag) |
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| 80R-1729 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human HSPA13 protein |
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) EIF3K protein (His tag) |
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| 80R-1730 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human EIF3K protein |
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) NECAP2 protein (His tag) |
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| 80R-1731 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human NECAP2 protein |
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) RDBP protein (His tag) |
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| 80R-1732 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human RDBP protein |
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) RGS2 protein (His tag) |
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| 80R-1733 | Fitzgerald | 10 ug | EUR 305 |
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Description: Purified recombinant Human RGS2 protein |
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) MTHFS protein (His tag) |
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| 80R-1734 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human MTHFS protein |
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) ZCCHC17 protein (His tag) |
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| 80R-1735 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human ZCCHC17 protein |
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) PDCD6 protein (His tag) |
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| 80R-1736 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human PDCD6 protein |
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) CAPSL protein (His tag) |
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| 80R-1737 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human CAPSL protein |
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) ALDOC protein (His tag) |
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| 80R-1738 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human ALDOC protein |
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) ALKBH3 protein (His tag) |
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| 80R-1739 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human ALKBH3 protein |
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) CMPK1 protein (His tag) |
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| 80R-1740 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human CMPK1 protein |
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) CSTA protein (His tag) |
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| 80R-1741 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human CSTA protein |
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) DECR1 protein (His tag) |
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| 80R-1742 | Fitzgerald | 50 ug | EUR 457 |
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Description: Purified recombinant Human DECR1 protein |
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) DNAJB11 protein (His tag) |
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| 80R-1743 | Fitzgerald | 10 ug | EUR 349 |
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Description: Purified recombinant Human DNAJB11 protein |
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) LGALS7 protein (His tag) |
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| 80R-1744 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human LGALS7 protein |
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) MORF4L2 protein (His tag) |
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| 80R-1745 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human MORF4L2 protein |
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) PKIB protein (His tag) |
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| 80R-1746 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human PKIB protein |
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) PPP3R2 protein (His tag) |
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| 80R-1747 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human PPP3R2 protein |
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) RBM8A protein (His tag) |
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| 80R-1748 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human RBM8A protein |
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) S100A7 protein (His tag) |
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| 80R-1749 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human S100A7 protein |
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) TPM4 protein (His tag) |
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| 80R-1750 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human TPM4 protein |
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) UBE2N protein (His tag) |
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| 80R-1751 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human UBE2N protein |
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) URM1 protein (His tag) |
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| 80R-1752 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human URM1 protein |
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) S100A13 protein (His tag) |
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| 80R-1753 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human S100A13 protein |
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) RCN2 protein (His tag) |
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| 80R-1754 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human RCN2 protein |
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) PSMB9 protein (His tag) |
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| 80R-1755 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human PSMB9 protein |
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) PIN4 protein (His tag) |
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| 80R-1756 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human PIN4 protein |
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) MAP2K3 protein (His tag) |
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| 80R-1757 | Fitzgerald | 10 ug | EUR 305 |
|
Description: Purified recombinant Human MAP2K3 protein |
|||
) IDI2 protein (His tag) |
|||
| 80R-1758 | Fitzgerald | 100 ug | EUR 397 |
|
Description: Purified recombinant Human IDI2 protein |
|||
) HSD17B8 protein (His tag) |
|||
| 80R-1759 | Fitzgerald | 100 ug | EUR 397 |
|
Description: Purified recombinant Human HSD17B8 protein |
|||
) RhoD protein (His tag) |
|||
| 80R-1760 | Fitzgerald | 10 ug | EUR 305 |
|
Description: Purified recombinant Human RhoD protein |
|||
) VASP protein (His tag) |
|||
| 80R-1761 | Fitzgerald | 50 ug | EUR 397 |
|
Description: Purified recombinant Human VASP protein |
|||
) KAAG1 protein (His tag) |
|||
| 80R-1762 | Fitzgerald | 10 ug | EUR 305 |
|
Description: Purified recombinant Human KAAG1 protein |
|||
) OSTN protein (His tag) |
|||
| 80R-1763 | Fitzgerald | 10 ug | EUR 305 |
|
Description: Purified recombinant Human OSTN protein |
|||
) AIF1 protein (His tag) |
|||
| 80R-1764 | Fitzgerald | 100 ug | EUR 305 |
|
Description: Purified recombinant Human AIF1 protein |
|||
) GSKIP protein (His tag) |
|||
| 80R-1765 | Fitzgerald | 100 ug | EUR 305 |
|
Description: Purified recombinant Human GSKIP protein |
|||
Familial dilated cardiomyopathy introduced on by a novel variant inside the Lamin A/C gene: a case report
Background: Familial dilated cardiomyopathy (FDCM) is usually inherited as an autosomal dominant trait. The Lamin A/C (LMNA) gene variants have been acknowledged to be associated to DCM, conductive system issues, variety 2 Emery-Dreifuss muscular dystrophy and plenty of different completely different issues. Proper right here, we reported a novel variant inside the LMNA gene that’s more likely to be related to FDCM.
Case presentation: A 30-year-old youthful man was hospitalized for chest tightness, extreme fatigue, palpitation and impaired train tolerance. He had scientific traits along with cardiac dilatation, atrial tachyarrhythmia, excessive conductive system issues, and dyskinesia of every greater limbs and the neck.
Genetic sequence analysis indicated that the affected particular person carried a novel c.1325 T>C heterozygous LMNA gene variant. Catheter ablation and cardiac resynchronization treatment with pacing carry out (CRT-P) have been carried out to take care of the arrhythmia.
Conclusion: The variant c.1325 T>C is a novel variant inside the LMNA gene that has not been beforehand reported. Youthful victims with DCM, conductive system issues and skeletal myopathy should be alert to the potential for LMNA gene variant.
Cardiac resynchronization treatment (CRT) is also an reasonably priced choice for affected particular person carrying a LMNA gene variant with third-degree atrioventricular block even when the left ventricular ejection fraction is preserved with the intention to cease the deterioration of cardiac carry out introduced on by correct ventricular pacing dependency.
Genetic analysis of children with congenital ocular anomalies in three ecological areas of Nepal: a piece II of Nepal pediatric ocular sicknesses analysis
Background: Genetic eye sicknesses characterize a giant and heterogeneous group of childhood ocular morbidity. Explicit particular person sicknesses may set off plenty of structural anomalies and developmental choices.
Nepal Pediatric Ocular Sickness Analysis (NPODS) was a population-based epidemiological analysis carried out all through three ecological areas of Nepal to search out out the prevalence and etiology of childhood ocular morbidity and blindness. In Half II of this analysis, genetic analysis was carried out for teenagers who’ve been found to have congenital ocular anomalies.
Methodology: It was a cross sectional descriptive analysis. An entire of 10,270 children all through three completely completely different ecological areas in Nepal (Low lands, hills, and mountains) underwent ocular examinations in NPODS. Out of 374 (3.6%) of children with ocular abnormalities, 30 have been thought of congenital in nature. Centered genetic analysis, along with genotyping for genes explicit to presenting phenotype, was carried out for 25 children using serum samples.
Outcomes: Out of 25 children, 18 had vital genetic outcomes. Analysis revealed one missense alteration G12411T of Zinc Finger Homeobox 4 (ZFHX4) gene in a single participant amongst 10 with congenital ptosis and one different missense variation T > C P. Y374 C of Signaling Receptor and Transporter Retinol 6 (STRA6) gene in a single participant amongst Three with microphthalmos.
Conclusion: The analysis is first of its type from Nepal and mutant genes have been distinctive to Nepalese Inhabitants. Further analysis of genetic elements is important to greater understand genetic affiliation with ocular sicknesses and conditions. This helps extra in genetic counseling and likely gene treatment to forestall blindness from these conditions.
Identification of diagnostic and prognostic biomarkers, and candidate targeted brokers for hepatitis B virus-associated early stage hepatocellular carcinoma based mostly totally on RNA-sequencing info
- Main liver most cancers is a shortly progressing neoplasm with extreme morbidity and mortality expenses. The present analysis aimed to find out potential diagnostic and prognostic biomarkers, and candidate targeted brokers for hepatitis B virus (HBV)-associated early stage hepatocellular carcinoma (HCC). The gene expression profiles had been extracted from the Gene Expression Omnibus database.
- Differentially expressed genes (DEGs), hub genes and the enrichment of signaling pathways had been filtered out by means of a high-throughput sequencing method. The affiliation between hub genes and the outcomes of the irregular expression of hub genes on the velocity of genetic variation, whole survival (OS), relapse-free survival (RFS), progression-free survival (PFS) and disease-free survival (DSS) of victims with HCC, along with pathological stage and grade, had been analyzed using fully completely different databases. An entire of 1,582 DEGs had been acknowledged.
- Gene Ontology analysis revealed that the DEGs had been primarily involved inside the ‘oxidation-reduction course of’, ‘steroid metabolic course of’, ‘metabolic course of’ and ‘fatty acid beta-oxidation’. Enrichment analysis of Kyoto Encyclopedia of Genes and Genomes pathways revealed that the DEGs had been primarily associated to ‘metabolic pathways’, ‘PPAR signaling pathway’, ‘fatty acid degradation’ and the ‘cell cycle’.
- An entire of Eight hub genes had been extracted. Furthermore, the irregular expression ranges of hub genes had been intently associated to the OS, RFS, PFS and DSS of victims, the pathological stage and the grade. Furthermore, irregular expression ranges of the Eight hub genes had been current in >30% of all samples.
- Plenty of small molecular compounds which is able to reverse the altered DEGs had been acknowledged based mostly totally on Connectivity Map analysis, along with phenoxybenzamine, GW-8510, resveratrol, 0175029-0000 and daunorubicin. In conclusion, the dysfunction of fat metabolic pathways, the cell cycle, oxidation-reduction processes and viral carcinogenesis would possibly serve very important roles inside the incidence of HBV-associated early stage HCC. The acknowledged Eight hub genes would possibly act as robust biomarkers for prognosis and prognosis. Some small molecular compounds is also promising targeted brokers in opposition to HBV-associated early stage HCC.
 Doxorubicin hydrochloride |
|||
| ADC-P-014 | Creative Biolabs | unit | Ask for price |
 Doxorubicin Hydrochloride |
|||
| 20-abx076623 | Abbexa |
|
|
Doxorubicin hydrochloride |
|||
| GA4969-100MG | Glentham Life Sciences | 100 mg | EUR 181 |
Doxorubicin hydrochloride |
|||
| GA4969-10MG | Glentham Life Sciences | 10 mg | EUR 78 |
Doxorubicin hydrochloride |
|||
| GA4969-25MG | Glentham Life Sciences | 25 mg | EUR 98 |
Doxorubicin hydrochloride |
|||
| GA4969-50MG | Glentham Life Sciences | 50 mg | EUR 126 |
 Doxorubicin hydrochloride USP |
|||
| D005-10MG | TOKU-E | 10 mg | EUR 166 |
Doxorubicin hydrochloride USP |
|||
| D005-25MG | TOKU-E | 25 mg | EUR 301 |
) Doxorubicin Hydrochloride (Autophagy inducer) |
|||
| SIH-390-10MG | Stressmarq | 10 mg | EUR 193 |
|
Description: The substance Doxorubicin Hydrochloride is a autophagy inducer. It is synthetically produced and has a purity of >98%. The pure substance is red solid which is soluble in water (50 mM).. |
|||
Doxorubicin Hydrochloride (Autophagy inducer) |
|||
| SIH-390-50MG | Stressmarq | 50 mg | EUR 529 |
|
Description: The substance Doxorubicin Hydrochloride is a autophagy inducer. It is synthetically produced and has a purity of >98%. The pure substance is red solid which is soluble in water (50 mM).. |
|||
 Erlotinib, Hydrochloride Salt |
|||
| 1588-100 | Biovision | EUR 169 | |
Erlotinib, Hydrochloride Salt |
|||
| 1588-1000 | Biovision | EUR 398 | |
 Doxorubicin |
|||
| D063-100MG | TOKU-E | 100 mg | EUR 1051 |
Doxorubicin |
|||
| D063-25MG | TOKU-E | 25 mg | EUR 322 |
Doxorubicin |
|||
| HY-15142A | MedChemExpress | 100mg | EUR 215 |
Doxorubicin |
|||
| ADC-P-013 | Creative Biolabs | unit | Ask for price |
Doxorubicin |
|||
| abx188695-1g | Abbexa | 1 g | EUR 467 |
Doxorubicin |
|||
| A3966-10 | ApexBio | 10 mg | EUR 108 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
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Doxorubicin |
|||
| A3966-100 | ApexBio | 100 mg | EUR 235 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
Doxorubicin |
|||
| A3966-25 | ApexBio | 25 mg | EUR 131 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
Doxorubicin |
|||
| A3966-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 131 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
Doxorubicin |
|||
| A3966-S | ApexBio | Evaluation Sample | EUR 81 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
 Erlotinib, Hydrochloride Salt, >99% |
|||
| BC026-101 | GenDepot | 1g | EUR 273 |
Erlotinib, Hydrochloride Salt, >99% |
|||
| BC026-102 | GenDepot | 2g | EUR 388 |
Erlotinib, Hydrochloride Salt, >99% |
|||
| BC026-105 | GenDepot | 5g | EUR 570 |
) Adriamycin (Doxorubicin) |
|||
| E1KS1208 | EnoGene | 10mg | EUR 409 |
 Doxorubicin HCl |
|||
| 20-abx184016 | Abbexa |
|
|
 Doxorubicin 10mM |
|||
| TG4120 | TopoGen | 0.25ml | EUR 156 |
 17-DMAG, Hydrochloride Salt, >98% |
|||
| BC024-001 | GenDepot | 1mg | EUR 178 |
17-DMAG, Hydrochloride Salt, >98% |
|||
| BC024-005 | GenDepot | 5mg | EUR 286 |
17-DMAG, Hydrochloride Salt, >98% |
|||
| BC024-010 | GenDepot | 10mg | EUR 408 |
17-DMAG, Hydrochloride Salt, >98% |
|||
| BC024-025 | GenDepot | 25mg | Ask for price |
 17-DMAG, Hydrochloride Salt, >99% |
|||
| BC024-100 | GenDepot | 100mg | Ask for price |
17-DMAG, Hydrochloride Salt, >99% |
|||
| BC024-101 | GenDepot | 1g | Ask for price |
17-DMAG, Hydrochloride Salt, >99% |
|||
| BC024-250 | GenDepot | 250mg | Ask for price |
 OSU-03012, Hydrochloride Salt, >98% |
|||
| BC061-005 | GenDepot | 5mg | EUR 313 |
OSU-03012, Hydrochloride Salt, >98% |
|||
| BC061-025 | GenDepot | 25mg | EUR 529 |
 Doxorubicin HCl, 100mg |
|||
| R2531-100mg | ACTGene | EUR 1300 | |
 Doxorubicin HCl, 10mg |
|||
| R2531-10mg | ACTGene | EUR 197 | |
 HCl) Doxorubicin (Adriamycin) HCl |
|||
| A1832-10 | ApexBio | 10 mg | EUR 125 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
Doxorubicin (Adriamycin) HCl |
|||
| A1832-100 | ApexBio | 100 mg | EUR 467 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
Doxorubicin (Adriamycin) HCl |
|||
| A1832-25 | ApexBio | 25 mg | EUR 189 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
Doxorubicin (Adriamycin) HCl |
|||
| A1832-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 113 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
 Anti-EGFR-doxorubicin ADC |
|||
| ADC-W-600 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-EGFR monoclonal antibody conjugated via a linker to a doxorubicin |
|||
 Anti-CD22-DIBO-doxorubicin ADC |
|||
| ADC-W-339 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-CD22 monoclonal antibody conjugated via a DIBO linker to a doxorubicin |
|||
-DIBO-doxorubicin ADC) Anti-TNFRSF8 (cAC10)-DIBO-doxorubicin ADC |
|||
| ADC-W-406 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (cAC10) conjugated via a DIBO linker to a doxorubicin |
|||
-NGM-doxorubicin ADC) Anti-ERBB2 (Trastuzumab)-NGM-doxorubicin ADC |
|||
| ADC-W-412 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-ERBB2 monoclonal antibody conjugated via a NGM linker to adoxorubicin |
|||
-SMCC-Doxorubicin ADC) Anti-EGFR (cetuximab)-SMCC-Doxorubicin ADC |
|||
| ADC-W-504 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-EGFR monoclonal antibody (cetuximab) conjugated via a SMCC linker to Doxorubicin |
|||
-hydrazone-Doxorubicin ADC) Anti-EpCAM (MOC31)-hydrazone-Doxorubicin ADC |
|||
| ADC-W-581 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-EPCAM monoclonal antibody (MOC31) conjugated via a hydrazone linker to Doxorubicin |
|||
-hydrazone-doxorubicin ADC) Anti-FUT3 (clone cBR96)-hydrazone-doxorubicin ADC |
|||
| ADC-W-423 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-FUT3 monoclonal antibody (clone cBR96) conjugated via a hydrazone linker to adoxorubicin |
|||
-β-glucuronide-doxorubicin ADC) Anti-CD70 (clone h1F6)-β-glucuronide-doxorubicin ADC |
|||
| ADC-W-376 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-CD70 monoclonal antibody (clone h1F6) conjugated via a β-glucuronide linker to a doxorubicin |
|||
 Bile salt |
|||
| BB0225 | Bio Basic | 25g | EUR 79.58 |
-β-glucuronide-doxorubicin propyloxazoline (DPO) ADC) Anti-TNFRSF8 (cCA10)-β-glucuronide-doxorubicin propyloxazoline (DPO) ADC |
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| ADC-W-353 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (cCA10) conjugated via a β-glucuronide linker to a doxorubicin propyloxazoline (DPO) |
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 Cell Nuclear Extract - Doxorubicin Stimulated) Human HeLa (Cervix Adenocarcinoma) Cell Nuclear Extract - Doxorubicin Stimulated |
|||
| HCL-2004 | Alpha Diagnostics | 100ug | EUR 225 |
 Whole Cell Lysate - Doxorubicin Stimulated) Human HeLa (Cervix Adenocarcinoma) Whole Cell Lysate - Doxorubicin Stimulated |
|||
| HCL-2010 | Alpha Diagnostics | 100ug | EUR 213 |
 THZ1 hydrochloride |
|||
| 9544-25 | Biovision | EUR 1023 | |
THZ1 hydrochloride |
|||
| 9544-5 | Biovision | EUR 305 | |
 Bestatin hydrochloride |
|||
| 9630-25 | Biovision | EUR 457 | |
Bestatin hydrochloride |
|||
| 9630-5 | Biovision | EUR 153 | |
 Ambroxol hydrochloride |
|||
| 9688-100 | Biovision | EUR 142 | |
Ambroxol hydrochloride |
|||
| 9688-500 | Biovision | EUR 262 | |
 Tetracycline, Hydrochloride |
|||
| CH054 | ABM | 25 g | EUR 119 |
Tetracycline, Hydrochloride |
|||
| CH055 | ABM | 100 g | EUR 170 |
 Palmatine hydrochloride |
|||
| TB0031 | ChemNorm | 10X20mg | EUR 274 |
 Triacetonamine hydrochloride |
|||
| TB01047 | ChemNorm | unit | Ask for price |
 Berberine hydrochloride |
|||
| TB0119-1000 | ChemNorm | 8XX20mg | EUR 274 |
 Betaine hydrochloride |
|||
| TB0136 | ChemNorm | 8XX20mg | EUR 274 |
 Sinomenine Hydrochloride |
|||
| TB0150 | ChemNorm | 6X20mg | EUR 257 |
 Ligustrazine Hydrochloride |
|||
| TB0189 | ChemNorm | 10X20mg | EUR 274 |
 Jatrorrhizine Hydrochloride |
|||
| TB0285 | ChemNorm | 3X20mg | EUR 291 |
 Leonurine Hydrochloride |
|||
| TB0408-0020 | ChemNorm | 20mg | EUR 228 |
 Leonurine hydrochloride |
|||
| TB0539 | ChemNorm | 3X20mg | EUR 291 |
 Berbamine hydrochloride |
|||
| TB0619 | ChemNorm | 8XX20mg | EUR 274 |
 Harmine hydrochloride |
|||
| TB0656 | ChemNorm | 5X20mg | EUR 274 |
 Trigonelline hydrochloride |
|||
| TB0720-0500 | ChemNorm | 8XX20mg | EUR 274 |
 Tomatidine hydrochloride |
|||
| TB0825-0025 | ChemNorm | 20mg | EUR 291 |
 Norglaucine hydrochloride |
|||
| TBP03165 | ChemNorm | 5mg | EUR 1144 |
 Dehydroevodiamine hydrochloride |
|||
| TBP03315 | ChemNorm | unit | Ask for price |
 Tetrahydropapaverine hydrochloride |
|||
| TBP03535 | ChemNorm | unit | Ask for price |
 Topotecan hydrochloride |
|||
| TBP03912 | ChemNorm | 4X20mg | EUR 268 |
 Irinotecan hydrochloride |
|||
| TBW00056 | ChemNorm | 5X20mg | EUR 274 |
Jatrorrhizine Hydrochloride |
|||
| TBW00130 | ChemNorm | 3X20mg | EUR 291 |
 Cephaeline hydrochloride |
|||
| TBW00304 | ChemNorm | 10mg | EUR 313 |
 Stachydrine hydrochloride |
|||
| TBW00307 | ChemNorm | 8XX25mg | EUR 274 |
 Ephedrine hydrochloride |
|||
| TBW00810 | ChemNorm | unit | Ask for price |
 Guvacine hydrochloride |
|||
| TBW01067 | ChemNorm | 20mg | Ask for price |
 Arecaidine hydrochloride |
|||
| TBW01500 | ChemNorm | 20mg | Ask for price |
 Norarecoline hydrochloride |
|||
| TBW01515 | ChemNorm | 20mg | Ask for price |
 Stylopine hydrochloride |
|||
| TBW01517 | ChemNorm | 20mg | Ask for price |
 Harmalol hydrochloride |
|||
| TBW01592 | ChemNorm | 10mg | Ask for price |
 Pilocarpine Hydrochloride |
|||
| TBZ2428 | ChemNorm | 100mg | Ask for price |
 Vasicine hydrochloride |
|||
| TBZ2592 | ChemNorm | 5mg | Ask for price |
 Tetrahydropalmatine hydrochloride |
|||
| TBZ2739 | ChemNorm | 20mg | Ask for price |
 Pioglitazone Hydrochloride |
|||
| TBZ2766 | ChemNorm | 20mg | Ask for price |
 Thiamine hydrochloride |
|||
| TBZ2784 | ChemNorm | 20mg | Ask for price |
 Emetine hydrochloride |
|||
| TBZ2803 | ChemNorm | 20mg | Ask for price |
 Serotonin hydrochloride |
|||
| TBZ2860 | ChemNorm | 20mg | Ask for price |
 Levomilnacipran hydrochloride |
|||
| TBZ3004 | ChemNorm | 5mg | Ask for price |
 EMetine Hydrochloride |
|||
| TRY0166 | ChemNorm | 20mg | Ask for price |
 Terbinafine hydrochloride |
|||
| B2657-250 | Biovision | 250 mg | EUR 196 |
Terbinafine hydrochloride |
|||
| B2657-50 | Biovision | 50 mg | EUR 115 |
 Bambuterol Hydrochloride |
|||
| B2679-10 | Biovision | 10 mg | EUR 115 |
Bambuterol Hydrochloride |
|||
| B2679-50 | Biovision | 50 mg | EUR 247 |
 Venlafaxine hydrochloride |
|||
| B2683-10 | Biovision | 10 mg | EUR 166 |
Venlafaxine hydrochloride |
|||
| B2683-50 | Biovision | 50 mg | EUR 510 |
 Valganciclovir Hydrochloride |
|||
| B2708-250 | Biovision | 250 mg | EUR 530 |
Valganciclovir Hydrochloride |
|||
| B2708-50 | Biovision | 50 mg | EUR 176 |
 Sinomenine hydrochloride |
|||
| B2741-10 | Biovision | 10 mg | EUR 115 |
Sinomenine hydrochloride |
|||
| B2741-50 | Biovision | 50 mg | EUR 313 |
 Valnemulin hydrochloride |
|||
| B2949-10 | Biovision | 10 mg | EUR 125 |
Valnemulin hydrochloride |
|||
| B2949-50 | Biovision | 50 mg | EUR 348 |
 Benserazide hydrochloride |
|||
| B2963-100 | Biovision | 100 mg | EUR 110 |
Benserazide hydrochloride |
|||
| B2963-500 | Biovision | 500 mg | EUR 293 |
 AMTB hydrochloride |
|||
| B2978-25 | Biovision | 25 mg | EUR 677 |
AMTB hydrochloride |
|||
| B2978-5 | Biovision | 5 mg | EUR 206 |
 Desipramine hydrochloride |
|||
| B2987-10 | Biovision | 10mg | EUR 110 |
Desipramine hydrochloride |
|||
| B2987-50 | Biovision | 50mg | EUR 287 |
 Guanfacine hydrochloride |
|||
| B2990-25 | Biovision | 25mg | EUR 287 |
Guanfacine hydrochloride |
|||
| B2990-5 | Biovision | 5mg | EUR 110 |
-Quinpirole hydrochloride) (-)-Quinpirole hydrochloride |
|||
| B2994-25 | Biovision | 25mg | EUR 510 |
(-)-Quinpirole hydrochloride |
|||
| B2994-5 | Biovision | 5mg | EUR 166 |
 Miglustat hydrochloride |
|||
| B3056-1 | Biovision | 1 mg | EUR 115 |
Miglustat hydrochloride |
|||
| B3056-5 | Biovision | 5 mg | EUR 313 |
 TAME Hydrochloride |
|||
| 2050-100 | Biovision | EUR 126 | |
TAME Hydrochloride |
|||
| 2050-1000 | Biovision | EUR 479 | |
TAME Hydrochloride |
|||
| 2050-500 | Biovision | EUR 338 | |
 Verapamil hydrochloride |
|||
| 2861-1G | Biovision | EUR 131 | |
Verapamil hydrochloride |
|||
| 2861-5G | Biovision | EUR 327 | |
 Ticlopidine hydrochloride |
|||
| 2919-25 | Biovision | EUR 403 | |
Ticlopidine hydrochloride |
|||
| 2919-5 | Biovision | EUR 153 | |
 EHNA hydrochloride |
|||
| 2265-25 | Biovision | EUR 283 | |
EHNA hydrochloride |
|||
| 2265-5 | Biovision | EUR 115 | |
 AdipoRon hydrochloride |
|||
| 2572-25 | Biovision | EUR 588 | |
AdipoRon hydrochloride |
|||
| 2572-5 | Biovision | EUR 185 | |
 Pargyline hydrochloride |
|||
| 2618-1000 | Biovision | EUR 175 | |
Pargyline hydrochloride |
|||
| 2618-500 | Biovision | EUR 120 | |
 Clorgyline hydrochloride |
|||
| 2622-10 | Biovision | EUR 120 | |
Clorgyline hydrochloride |
|||
| 2622-50 | Biovision | EUR 327 | |
 Clindamycin hydrochloride |
|||
| 2627-10 | Biovision | EUR 131 | |
Clindamycin hydrochloride |
|||
| 2627-50 | Biovision | EUR 370 | |
 Loperamide hydrochloride |
|||
| 2683-1000 | Biovision | EUR 185 | |
Loperamide hydrochloride |
|||
| 2683-500 | Biovision | EUR 131 | |
 Clonidine hydrochloride |
|||
| 2684-100 | Biovision | EUR 131 | |
Clonidine hydrochloride |
|||
| 2684-500 | Biovision | EUR 359 | |
 Leelamine hydrochloride |
|||
| 2717-25 | Biovision | EUR 457 | |
Leelamine hydrochloride |
|||
| 2717-5 | Biovision | EUR 153 | |
 SBE13 hydrochloride |
|||
| 2847-10 | Biovision | EUR 185 | |
SBE13 hydrochloride |
|||
| 2847-50 | Biovision | EUR 588 | |
 Metformin, Hydrochloride |
|||
| 1691-5G | Biovision | EUR 158 | |
 Irinotecan Hydrochloride |
|||
| 1752-250 | Biovision | EUR 387 | |
Irinotecan Hydrochloride |
|||
| 1752-50 | Biovision | EUR 147 | |
 Epirubicin Hydrochloride |
|||
| 1753-25 | Biovision | EUR 457 | |
Epirubicin Hydrochloride |
|||
| 1753-5 | Biovision | EUR 158 | |
 Gemcitabine Hydrochloride |
|||
| 1759-100 | Biovision | EUR 370 | |
Gemcitabine Hydrochloride |
|||
| 1759-25 | Biovision | EUR 156 | |
 Amiodarone Hydrochloride |
|||
| 1828-100 | Biovision | EUR 126 | |
Amiodarone Hydrochloride |
|||
| 1828-500 | Biovision | EUR 338 | |
 Phenformin hydrochloride |
|||
| 1889-100 | Biovision | EUR 115 | |
Phenformin hydrochloride |
|||
| 1889-1000 | Biovision | EUR 359 | |
Tomatidine hydrochloride |
|||
| 1893-25 | Biovision | EUR 137 | |
 Vancomycin Hydrochloride |
|||
| B1507-1G | Biovision | EUR 153 | |
Vancomycin Hydrochloride |
|||
| B1507-250 | Biovision | EUR 120 | |
Vancomycin Hydrochloride |
|||
| B1507-5G | Biovision | EUR 262 | |
 Lincomycin Hydrochloride |
|||
| B1524-1G | Biovision | EUR 142 | |
Lincomycin Hydrochloride |
|||
| B1524-5G | Biovision | EUR 403 | |
 Minocycline Hydrochloride |
|||
| B1525-250 | Biovision | EUR 414 | |
Minocycline Hydrochloride |
|||
| B1525-50 | Biovision | EUR 142 | |
 Oxytetracycline Hydrochloride |
|||
| B1527-25G | Biovision | EUR 229 | |
Oxytetracycline Hydrochloride |
|||
| B1527-5G | Biovision | EUR 109 | |
 Tetracycline Hydrochloride |
|||
| B1535-10G | Biovision | EUR 109 | |
Tetracycline Hydrochloride |
|||
| B1535-50G | Biovision | EUR 196 | |
 Hydroxyfasudil Hydrochloride |
|||
| B1559-25 | Biovision | EUR 631 | |
Hydroxyfasudil Hydrochloride |
|||
| B1559-5 | Biovision | EUR 196 | |
 Thioridazine Hydrochloride |
|||
| B1581-1G | Biovision | EUR 120 | |
Thioridazine Hydrochloride |
|||
| B1581-5G | Biovision | EUR 327 | |
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