Project Description

Chemical Structure

AG-221 (Cas#1446502-11-9)

Chemical Name: 2-methyl-1-((4-(6-(trifluoromethyl)pyridin-2-yl)-6-((2-(trifluoromethyl)pyridin-4-yl)amino)-1,3,5-triazin-2-yl)amino)propan-2-ol
SMILES Code: CC(O)(C)CNC1=NC(C2=NC(C(F)(F)F)=CC=C2)
=NC(NC3=CC(C(F)(F)F)=NC=C3)=N1

Theoretical Analysis

MetonChem Cat#: MC6070201
Product Name: AG-221
CAS#: 1446502-11-9
Synonym: Enasidenib, AG 221; AG221; CC-90007; CC 90007; CC90007
Chemical Formula: C19H17F6N7O
Molecular Weight: 473.38

Technical Data

Appearance: Solid powder
Purity: >98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water

Background Description

AG-221 (Enasidenib, CC-90007) is a potent and selective IDH2 inhibitor with potential anticancer activity. The mutations of IDH2 present in certain cancer cells result in a new ability of the enzyme to catalyze the NAPH-dependent reduction of α-ketoglutarate to R(-)-2-hydroxyglutarate (2HG). The production of 2HG is believed to contribute to the formation and progression of cancer. The inhibition of mutant IDH2 and its neoactivity is therefore a potential therapeutic treatment for cancer.

More details, please refer to
https://ash.confex.com/ash/2014/webprogram/Paper70721.html

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