Project Description

Chemical Structure

AG-120 (Cas#1448346-63-1)

Chemical Name: (2S)-N-(1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
SMILES Code: O=C([C@H](CC1)N(C2=NC=CC(C#N)=C2)C1=O)N
(C(C3=CC=CC=C3Cl)C(NC4CC(F)(F)C4)=O)C5=CC(F)=CN=C5

Theoretical Analysis

MetonChem Cat#: MC6060801
Product Name: AG-120
CAS#: 1448346-63-1
Synonym: AG120; AG 120; Ivosidenib
Chemical Formula: C28H22ClF3N6O3
Molecular Weight: 582.97

Technical Data

Appearance: Solid powder
Purity: >98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water

Background Description

AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Upon administration, AG-120 specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG).

For pricing & availability, or other questions, please send emails to sales@metonchem.com.
Or fill out the following form.

Fill out my online form.