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H-89 is a potent inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase, and others kinases.
Cadazolid (ACT-179811) is a novel oxazolidinone antibiotic with potent activity against Clostridium difficile, a major cause of drug resistant diarrhea in the elderly.
Mitoquinone (MitoQ10,MitoQ) mesylate is a mitochondria-targeted antioxidant designed to accumulate within mitochondria in vivo in order to protect against oxidative damage.
GNF179 is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability.
VcMMAE is a MMAE derivative with valine-citrulline (Vc) linker, which can be used to make antibody drug conjugate. VcMMAE is a anti-mitotic agent, monomethyl auristatin E.
SNS-314 is a synthetic small molecule Aurora kinase (AK) inhibitor with potential antineoplastic activity. Aurora kinase inhibitor SNS-314 selectively binds to and inhibits AKs A and B.
PF-06273340 is a potent and selective pan-Trk inhibitor (IC50 values are 1, 2 and 6 nM for Trk C, B and A, respectively). It is selective for Trk over a panel of ion channels, receptors and other enzymes.
LXS-196 is a potent and orally active protein kinase C inhibitor for the treatment of uveal melanoma.
CB-03-01 (Cortexolone 17 alpha-propionate) is a new topical and peripherally selective androgen antagonist. It is a new potent topical antiandrogen potentially useful in acne vulgaris.
Doravirine (MK-1439) is a novel non-nucleoside inhibitor of HIV-1 reverse transcriptase with potent activity against wild-type virus (95% inhibitory concentration 19 nM, 50% human serum).
BMS-663068 (Fostemsavir) is the phosphonooxymethyl prodrug of BMS-626529. BMS-626529 is a novel attachment inhibitor that targets HIV-1 gp120 ...
Relebactam (MK-7655) is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases. It potentiated imipenem against Enterobacteriaceae with KPC ...
TX1-85-1 is ErbB3 inhibitor. TX2-121-1 may exert Her3-dependent pharmacology through an allosteric mechanismthereby disrupting interactions between Her3 and other proteins.
PF-06273340 is potent and selective pan-Trk inhibitor (IC50 values are 1, 2 and 6 nM for Trk C, B and A, respectively). It is elective for Trk over a panel of ion channels, receptors and other enzymes.
Tacrolimus (FK-506; Fujimycin; FR900506; FK506; FK 506) is an immunosuppressive drug used mainly after allogeneic organ transplant to reduce the activity of the patient's immune system ...
Moxidectin(ProHeart 6; CL301423; Cydectin) is an anthelmintic drug which kills parasitic worms (helminths), and is used for the prevention and control of heartworm and intestinal worms.
Nemorubicin(Methoxymorpholinyl doxorubicin; PNU152243) is a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile.
Tildipirosin is a novel 16-membered-ring macrolide authorized for the treatment of bovine and swine respiratory disease. It is developed to treat bacterial pathogens ...
Dalbavancin(BI-397, MDL-63397) is a semisynthetic lipoglycopeptide, has potent activity against Gram-positive bacteria. It has a half-life of 5 to 7 days in humans and offers promise for a convenient ...
Oritavancin (LY333328) diphosphate is a novel semisynthetic glycopeptide antibiotic being developed for the treatment of serious Gram-positive bacterial infections.
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