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Bioactive molecules >
Otamixaban(FXV673) is a potent (Ki = 0.5 nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa.
Edoxaban (DU-176) is a potent, selective factor Xa inhibitor, which has good oral bioavailability. It is an anticoagulant drug which acts as a direct factor Xa inhibitor.
Dabigatran (BIBR 953) is an oral anticoagulant from the class of the direct thrombin inhibitors. It is being studied for various clinical indications.
Apixaban (BMS-56224701) is an anticoagulant for the treatment of venous thromboembolic events. It is a direct factor Xa inhibitor.
Rivaroxaban (BAY 59-7939) is an oral anticoagulant invented and manufactured by Bayer; in a number of countries it is marketed as Xarelto.
Ticagrelor is a platelet aggregation inhibitor produced by AstraZeneca. It is absorbed quickly from the gut, the bioavailability being 36%, and reaches its peak concentration after about 1.5 hours.
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